ZNF365
Protein ZNF365 is a protein that in humans is encoded by the ZNF365 gene.[5][6][7]
Model organisms
Model organisms have been used in the study of ZNF365 function. A conditional knockout mouse line called Zfp365tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[8] Male and female animals underwent a standardized phenotypic screen[9] to determine the effects of deletion.[10][11][12][13] Additional screens performed: - In-depth immunological phenotyping[14] - in-depth bone and cartilage phenotyping[15]
| Characteristic | Phenotype |
|---|---|
| All data available at.[9][14][15] | |
| Peripheral blood leukocytes 6 Weeks | Normal |
| Haematology 6 Weeks | Abnormal |
| Insulin | Normal |
| Homozygous viability at P14 | Normal |
| Homozygous Fertility | Normal |
| Body weight | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Dysmorphology | Normal |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Normal |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology 16 Weeks | Normal |
| Peripheral blood leukocytes 16 Weeks | Normal |
| Heart weight | Normal |
| Salmonella infection | Normal |
| Cytotoxic T Cell Function | Normal |
| Spleen Immunophenotyping | Normal |
| Mesenteric Lymph Node Immunophenotyping | Normal |
| Bone Marrow Immunophenotyping | Normal |
| Epidermal Immune Composition | Normal |
| Influenza Challenge | Normal |
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138311 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037855 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
- ^ Gianfrancesco F, Esposito T, Ombra MN, Forabosco P, Maninchedda G, Fattorini M, Casula S, Vaccargiu S, Casu G, Cardia F, Deiana I, Melis P, Falchi M, Pirastu M (Jun 2003). "Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate". American Journal of Human Genetics. 72 (6): 1479–91. doi:10.1086/375628. PMC 1180308. PMID 12740763.
- ^ "Entrez Gene: ZNF365 zinc finger protein 365".
- ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
- ^ a b "International Mouse Phenotyping Consortium".
- ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
- ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
- ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
- ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium".
- ^ a b "OBCD Consortium".
Further reading
- Ombra MN, Forabosco P, Casula S, Angius A, Maestrale G, Petretto E, Casu G, Colussi G, Usai E, Melis P, Pirastu M (May 2001). "Identification of a new candidate locus for uric acid nephrolithiasis". American Journal of Human Genetics. 68 (5): 1119–29. doi:10.1086/320105. PMC 1226093. PMID 11309680.
- Gianfrancesco F, Esposito T, Casu G, Maninchedda G, Roberto R, Pirastu M (Sep 2004). "Emergence of Talanin protein associated with human uric acid nephrolithiasis in the Hominidae lineage". Gene. 339: 131–8. doi:10.1016/j.gene.2004.06.030. PMID 15363853.
- Wang Q, Du X, Meinkoth J, Hirohashi Y, Zhang H, Liu Q, Richter M, Greene MI (Apr 2006). "Characterization of Su48, a centrosome protein essential for cell division". Proceedings of the National Academy of Sciences of the United States of America. 103 (17): 6512–7. Bibcode:2006PNAS..103.6512W. doi:10.1073/pnas.0601682103. PMC 1458915. PMID 16617106.
- Hirohashi Y, Wang Q, Liu Q, Li B, Du X, Zhang H, Furuuchi K, Masuda K, Sato N, Greene MI (Oct 2006). "Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation". Oncogene. 25 (45): 6048–55. doi:10.1038/sj.onc.1209637. PMID 16682949.
External links
- ZNF365+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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