Ets variant 5

Search for
Structures	Swiss-model
Domains	InterPro

ets variant gene 5 (ets-related molecule)
ets variant gene 5 (ets-related molecule)
Identifiers
Symbol	ETV5
Alt. symbols	ERM
NCBI gene	2119
HGNC	3494
OMIM	601600
RefSeq	NM_004454
UniProt	P41161
Other data
Locus	Chr. 3 q28
Structures
Search for
Structures	Swiss-model
Domains	InterPro

ETV5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UNO
Identifiers
Aliases	ETV5, ERM, ETS variant 5, ETS variant transcription factor 5
External IDs	OMIM: 601600; MGI: 1096867; HomoloGene: 3276; GeneCards: ETV5; OMA:ETV5 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	186,110,318 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	22,258,469 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; ventricular zone; ; secondary oocyte; ; ganglionic eminence; ; caput epididymis; ; Brodmann area 46; ; prefrontal cortex; ; placenta; ; pituitary gland; ; gonad;
	Top expressed in
	tail of embryo; ; epiblast; ; lung; ; palate; ; soft palate; ; yolk sac; ; Cortex of frontal lobe; ; embryo; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus; plasma membrane;
Biological process	cell differentiation; regulation of transcription, DNA-templated; locomotory behavior; regulation of branching involved in mammary gland duct morphogenesis; positive regulation of transcription, DNA-templated; neuromuscular synaptic transmission; male germ-line stem cell asymmetric division; positive regulation of neuron differentiation; skeletal muscle acetylcholine-gated channel clustering; cellular response to oxidative stress; positive regulation of glial cell proliferation; regulation of synapse organization; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2119
	104156
	ENSG00000244405
	ENSMUSG00000013089
	P41161
	Q9CXC9
	NM_004454
	NM_023794; NM_001358428
	NP_004445
	NP_076283; NP_001345357
	Wikidata
View/Edit Human	View/Edit Mouse

Ets variant 5 (ETV5) (also named ERM transcription factor) is a transcription factor that in humans is encoded by the ETV5 gene.^[5] It is generated in Sertoli cells, which are found in the testes and play a crucial role in spermatogenesis. Its ortholog has been linked to both obesity and bipolar disorder.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000244405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013089 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Ets variant 5".
^ Williams MJ, Klockars A, Eriksson A, Voisin S, Dnyansagar R, Wiemerslage L, Kasagiannis A, Akram M, Kheder S, Ambrosi V, Hallqvist E, Fredriksson R, Schiöth HB (June 2016). "The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder". PLOS Genetics. 12 (6): e1006104. doi:10.1371/journal.pgen.1006104. PMC 4900636. PMID 27280443.

T'sas F, Brenner C, Mauen S, Putmans P, Monté D, Van Lint C, Moser M, Baert JL, de Launoit Y (January 2005). "Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line". FEBS Letters. 579 (1): 66–70. Bibcode:2005FEBSL.579...66T. doi:10.1016/j.febslet.2004.11.052. PMID 15620692. S2CID 25112599.
Brandys MK, van Elburg AA, Loos RJ, Bauer F, Hendriks J, van der Schouw YT, Adan RA (March 2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409. S2CID 45793585.
Colas E, Muinelo-Romay L, Alonso-Alconada L, Llaurado M, Monge M, Barbazan J, Gonzalez M, Schoumacher M, Pedrola N, Ertekin T, Devis L, Ruiz A, Castellvi J, Doll A, Gil-Moreno A, Vazquez-Levin M, Lapyckyj L, Lopez-Lopez R, Robine S, Friederich E, Castro M, Reventos J, Vignjevic D, Abal M (November 2012). "ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas". Oncogene. 31 (45): 4778–88. doi:10.1038/onc.2011.632. hdl:11336/22664. PMID 22266854.
Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C (November 2001). "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". The Journal of Biological Chemistry. 276 (44): 40417–23. doi:10.1074/jbc.M104765200. PMID 11509567.
Korz C, Pscherer A, Benner A, Mertens D, Schaffner C, Leupolt E, Döhner H, Stilgenbauer S, Lichter P (June 2002). "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood. 99 (12): 4554–61. doi:10.1182/blood.V99.12.4554. PMID 12036888.
Chotteau-Lelièvre A, Révillion F, Lhotellier V, Hornez L, Desbiens X, Cabaret V, de Launoit Y, Peyrat JP (November 2004). "Prognostic value of ERM gene expression in human primary breast cancers". Clinical Cancer Research. 10 (21): 7297–303. doi:10.1158/1078-0432.CCR-04-0593. PMID 15534105. S2CID 14271353.
Planagumà J, Liljeström M, Alameda F, Bützow R, Virtanen I, Reventós J, Hukkanen M (January 2011). "Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma". Human Pathology. 42 (1): 57–67. doi:10.1016/j.humpath.2010.01.025. PMID 20970160.
Monge M, Colas E, Doll A, Gil-Moreno A, Castellvi J, Diaz B, Gonzalez M, Lopez-Lopez R, Xercavins J, Carreras R, Alameda F, Canals F, Gabrielli F, Reventos J, Abal M (August 2009). "Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress". Carcinogenesis. 30 (8): 1288–97. doi:10.1093/carcin/bgp119. PMID 19443906.
Ng MC, Tam CH, So WY, Ho JS, Chan AW, Lee HM, Wang Y, Lam VK, Chan JC, Ma RC (May 2010). "Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese". The Journal of Clinical Endocrinology and Metabolism. 95 (5): 2418–25. doi:10.1210/jc.2009-2077. PMID 20215397.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

External links

ERM+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ETV5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000244405 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013089 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ets variant 5".

[Williams2016-6] Williams MJ, Klockars A, Eriksson A, Voisin S, Dnyansagar R, Wiemerslage L, Kasagiannis A, Akram M, Kheder S, Ambrosi V, Hallqvist E, Fredriksson R, Schiöth HB (June 2016). "The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder". PLOS Genetics. 12 (6): e1006104. doi:10.1371/journal.pgen.1006104. PMC 4900636. PMID 27280443.

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References

Further reading

External links