NFX1

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NFX1
Identifiers
AliasesNFX1, NFX2, TEG-42, Tex42, nuclear transcription factor, X-box binding 1
External IDsOMIM: 603255 MGI: 1921414 HomoloGene: 1875 GeneCards: NFX1
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for NFX1
Genomic location for NFX1
Band9p13.3Start33,290,512 bp[1]
End33,371,157 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002504
NM_147133
NM_147134
NM_001318758

NM_001290448
NM_001290449
NM_023739

RefSeq (protein)

NP_001305687
NP_002495
NP_667345

NP_001277377
NP_001277378
NP_076228

Location (UCSC)Chr 9: 33.29 – 33.37 MbChr 4: 40.97 – 41.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.[5][6][7]

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000086102 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028423 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Song Z, Krishna S, Thanos D, Strominger JL, Ono SJ (Dec 1994). "A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor". J Exp Med. 180 (5): 1763–74. doi:10.1084/jem.180.5.1763. PMC 2191754. PMID 7964459.
  6. ^ Hume CR, Lee JS (Jan 1990). "Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors". Hum Immunol. 26 (4): 288–309. doi:10.1016/0198-8859(89)90007-4. PMID 2511169.
  7. ^ Arlotta P, Miyazaki D, Copeland NG, Gilbert DJ, Jenkins NA, Ono SJ (June 2002). "Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression". Immunology. 106 (2): 173–81. doi:10.1046/j.1365-2567.2002.01416.x. PMC 1782705. PMID 12047746.
  8. ^ "Entrez Gene: NFX1 nuclear transcription factor, X-box binding 1".

Further reading[edit]

External links[edit]