NFX1

NFX1
Identifiers
Aliases	NFX1, NFX2, TEG-42, Tex42, nuclear transcription factor, X-box binding 1
External IDs	OMIM: 603255; MGI: 1921414; HomoloGene: 1875; GeneCards: NFX1; OMA:NFX1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	33,371,157 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	41,025,993 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; skin of hip; ; tail of epididymis; ; caput epididymis; ; corpus epididymis; ; endothelial cell; ; right ventricle; ; oral cavity; ; skin of thigh; ; biceps brachii;
	Top expressed in
	cumulus cell; ; primitive streak; ; epiblast; ; gastrula; ; seminal vesicula; ; dermis; ; neural layer of retina; ; hair follicle; ; superior frontal gyrus; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; zinc ion binding; ligase activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; metal ion binding; nucleic acid binding; RNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transferase activity; ubiquitin protein ligase activity;
Cellular component	plasma membrane; nucleolus; nucleus; cytosol;
Biological process	inflammatory response; viral process; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of MHC class II biosynthetic process; transcription, DNA-templated; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	4799
	74164
	ENSG00000086102
	ENSMUSG00000028423
	Q12986
	B1AY10
	NM_002504; NM_147133; NM_147134; NM_001318758
	NM_001290448; NM_001290449; NM_023739
	NP_001305687; NP_002495; NP_667345
	NP_001277377; NP_001277378; NP_076228
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene.^[5]^[6]^[7]

MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000086102 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028423 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Song Z, Krishna S, Thanos D, Strominger JL, Ono SJ (Dec 1994). "A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor". J Exp Med. 180 (5): 1763–74. doi:10.1084/jem.180.5.1763. PMC 2191754. PMID 7964459.
^ Hume CR, Lee JS (Jan 1990). "Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors". Hum Immunol. 26 (4): 288–309. doi:10.1016/0198-8859(89)90007-4. PMID 2511169.
^ Arlotta P, Miyazaki D, Copeland NG, Gilbert DJ, Jenkins NA, Ono SJ (June 2002). "Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression". Immunology. 106 (2): 173–81. doi:10.1046/j.1365-2567.2002.01416.x. PMC 1782705. PMID 12047746.
^ "Entrez Gene: NFX1 nuclear transcription factor, X-box binding 1".

External links

NFX1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000086102 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028423 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7964459-5] Song Z, Krishna S, Thanos D, Strominger JL, Ono SJ (Dec 1994). "A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor". J Exp Med. 180 (5): 1763–74. doi:10.1084/jem.180.5.1763. PMC 2191754. PMID 7964459.

[pmid2511169-6] Hume CR, Lee JS (Jan 1990). "Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors". Hum Immunol. 26 (4): 288–309. doi:10.1016/0198-8859(89)90007-4. PMID 2511169.

[pmid12047746-7] Arlotta P, Miyazaki D, Copeland NG, Gilbert DJ, Jenkins NA, Ono SJ (June 2002). "Murine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expression". Immunology. 106 (2): 173–81. doi:10.1046/j.1365-2567.2002.01416.x. PMC 1782705. PMID 12047746.

[entrez-8] "Entrez Gene: NFX1 nuclear transcription factor, X-box binding 1".

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References

Further reading

External links