Myogenin: Difference between revisions
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*{{cite journal | author=Groisman R, Masutani H, Leibovitch MP, ''et al.'' |title=Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5258–64 |year= 1996 |pmid= 8617811 |doi=10.1074/jbc.271.9.5258 }} |
*{{cite journal | author=Groisman R, Masutani H, Leibovitch MP, ''et al.'' |title=Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5258–64 |year= 1996 |pmid= 8617811 |doi=10.1074/jbc.271.9.5258 }} |
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*{{cite journal | author=Chen CM, Kraut N, Groudine M, Weintraub H |title=I-mf, a novel myogenic repressor, interacts with members of the MyoD family. |journal=Cell |volume=86 |issue= 5 |pages= 731–41 |year= 1996 |pmid= 8797820 |doi=10.1016/S0092-8674(00)80148-8 }} |
*{{cite journal | author=Chen CM, Kraut N, Groudine M, Weintraub H |title=I-mf, a novel myogenic repressor, interacts with members of the MyoD family. |journal=Cell |volume=86 |issue= 5 |pages= 731–41 |year= 1996 |pmid= 8797820 |doi=10.1016/S0092-8674(00)80148-8 }} |
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*{{cite journal | author=Kong Y, Flick MJ, Kudla AJ, Konieczny SF |title=Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. |journal=Mol. Cell. Biol. |volume=17 |issue= 8 |pages= 4750–60 |year= 1997 |pmid= 9234731 |doi= | pmc=232327 }} |
*{{cite journal | author=Kong Y, Flick MJ, Kudla AJ, Konieczny SF |title=Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. |journal=Mol. Cell. Biol. |volume=17 |issue= 8 |pages= 4750–60 |year= 1997 |pmid= 9234731 |doi= 10.1073/pnas.0405488102| pmc=232327 | bibcode=2005PNAS..102.1655H }} |
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*{{cite journal | author=Langlands K, Yin X, Anand G, Prochownik EV |title=Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19785–93 |year= 1997 |pmid= 9242638 |doi=10.1074/jbc.272.32.19785 }} |
*{{cite journal | author=Langlands K, Yin X, Anand G, Prochownik EV |title=Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19785–93 |year= 1997 |pmid= 9242638 |doi=10.1074/jbc.272.32.19785 }} |
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*{{cite journal | author=Biesiada E, Hamamori Y, Kedes L, Sartorelli V |title=Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 2577–84 |year= 1999 |pmid= 10082523 |doi= | pmc=84050 }} |
*{{cite journal | author=Biesiada E, Hamamori Y, Kedes L, Sartorelli V |title=Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 2577–84 |year= 1999 |pmid= 10082523 |doi= | pmc=84050 }} |
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Revision as of 12:14, 18 March 2011
Template:PBB Myogenin (myogenic factor 4), also known as MYOG, is a gene.[1]
Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and Mrf4.
In mice, myogenin is essential for the development of functional skeletal muscle. When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body.
In cell culture, myogenin can induce myogenesis in a variety of non-muscle cell types.
Interactions
Myogenin has been shown to interact with POLR2C,[2] Sp1 transcription factor,[3] TCF3,[4][5] Serum response factor[3][6] and MDFI.[7]
References
- ^ "Entrez Gene: MYOG myogenin (myogenic factor 4)".
- ^ Corbi, Nicoletta (2002). "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin". FASEB J. 16 (12). United States: 1639–41. doi:10.1096/fj.02-0123fje. PMID 12207009.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: unflagged free DOI (link) - ^ a b Biesiada, E (1999). "Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter". Mol. Cell. Biol. 19 (4). UNITED STATES: 2577–84. ISSN 0270-7306. PMC 84050. PMID 10082523.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Langlands, K (1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32). UNITED STATES: 19785–93. doi:10.1074/jbc.272.32.19785. ISSN 0021-9258. PMID 9242638.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: unflagged free DOI (link) - ^ Chakraborty, T (1992). "Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system". J. Biol. Chem. 267 (25). UNITED STATES: 17498–501. ISSN 0021-9258. PMID 1325437.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Groisman, R (1996). "Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins". J. Biol. Chem. 271 (9). UNITED STATES: 5258–64. doi:10.1074/jbc.271.9.5258. ISSN 0021-9258. PMID 8617811.
{{cite journal}}: Check date values in:|year=(help); Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: unflagged free DOI (link) - ^ Chen, C M (1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family". Cell. 86 (5). UNITED STATES: 731–41. doi:10.1016/S0092-8674(00)80148-8. ISSN 0092-8674. PMID 8797820.
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Further reading
External links
- Myogenin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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