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STAT2

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Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene.[1][2] It is a member of the STAT protein family.

Function

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.[2]

Interactions

STAT2 has been shown to interact with:

References

  1. ^ Yan R, Qureshi S, Zhong Z, Wen Z, Darnell JE (Feb 1995). "The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2". Nucleic Acids Research. 23 (3): 459–63. doi:10.1093/nar/23.3.459. PMC 306697. PMID 7885841.
  2. ^ a b "Entrez Gene: STAT2 signal transducer and activator of transcription 2, 113kDa".
  3. ^ Bhattacharya S, Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston DM (Sep 1996). "Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha". Nature. 383 (6598): 344–7. doi:10.1038/383344a0. PMID 8848048.
  4. ^ a b Li X, Leung S, Kerr IM, Stark GR (Apr 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Molecular and Cellular Biology. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
  5. ^ Uddin S, Chamdin A, Platanias LC (Oct 1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor". The Journal of Biological Chemistry. 270 (42): 24627–30. doi:10.1074/jbc.270.42.24627. PMID 7559568.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  6. ^ Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (Mar 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein". The EMBO Journal. 15 (5): 1064–74. PMC 450004. PMID 8605876.
  7. ^ Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ (Mar 2002). "Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling". The Journal of Biological Chemistry. 277 (12): 9713–21. doi:10.1074/jbc.M111161200. PMID 11786546.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  8. ^ Horvath CM, Stark GR, Kerr IM, Darnell JE (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Molecular and Cellular Biology. 16 (12): 6957–64. doi:10.1128/mcb.16.12.6957. PMC 231699. PMID 8943351.
  9. ^ Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". The Journal of Biological Chemistry. 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. PMID 9242679.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  10. ^ Lau JF, Nusinzon I, Burakov D, Freedman LP, Horvath CM (Jan 2003). "Role of metazoan mediator proteins in interferon-responsive transcription". Molecular and Cellular Biology. 23 (2): 620–8. doi:10.1128/mcb.23.2.620-628.2003. PMC 151539. PMID 12509459.
  11. ^ Huang M, Qian F, Hu Y, Ang C, Li Z, Wen Z (Oct 2002). "Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes". Nature Cell Biology. 4 (10): 774–81. doi:10.1038/ncb855. PMID 12244326.
  12. ^ Li X, Leung S, Qureshi S, Darnell JE, Stark GR (Mar 1996). "Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha". The Journal of Biological Chemistry. 271 (10): 5790–4. doi:10.1074/jbc.271.10.5790. PMID 8621447.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  13. ^ Dumler I, Kopmann A, Wagner K, Mayboroda OA, Jerke U, Dietz R, Haller H, Gulba DC (Aug 1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". The Journal of Biological Chemistry. 274 (34): 24059–65. doi:10.1074/jbc.274.34.24059. PMID 10446176.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  14. ^ Fagerlund R, Mélen K, Kinnunen L, Julkunen I (Aug 2002). "Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5". The Journal of Biological Chemistry. 277 (33): 30072–8. doi:10.1074/jbc.M202943200. PMID 12048190.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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