IRF4: Difference between revisions
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{{PBB|geneid=3662}} __NOTOC__ |
{{PBB|geneid=3662}} __NOTOC__ |
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'''Interferon regulatory factor 4''' is a [[protein]] that in humans is encoded by the ''IRF4'' [[gene]],<ref name="pmid8921401">{{cite journal | author = Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW | title = Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25 | journal = Genomics | volume = 37 | issue = 2 | pages = 229–33 | year = 1997 | month = Feb | pmid = 8921401 | pmc = | doi = 10.1006/geno.1996.0547 }}</ref><ref name="pmid18417578">{{cite journal | author = Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L | title = Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes | journal = J Virol | volume = 82 | issue = 13 | pages = 6251–8 | year = 2008 | month = Jun | pmid = 18417578 | pmc = 2447047 | doi = 10.1128/JVI.00163-08 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IRF4 interferon regulatory factor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3662| accessdate = }}</ref> also known as ''MUM1''. In melanocytic cells the IRF4 gene may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | author = Hoek KS, Schlegel NC, Eichhoff OM, ''et al.'' | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref> IRF4 is a transcription factor that has been implicated in acute leukemia.<ref>Implication of IRF4 aberrant gene expression in the acute leukemias of childhood. PLoS One. 2013 Aug 15;8(8):e72326. doi: 10.1371/journal.pone.0072326.</ref> |
'''Interferon regulatory factor 4''' is a [[protein]] that in humans is encoded by the ''IRF4'' [[gene]],<ref name="pmid8921401">{{cite journal | author = Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW | title = Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25 | journal = Genomics | volume = 37 | issue = 2 | pages = 229–33 | year = 1997 | month = Feb | pmid = 8921401 | pmc = | doi = 10.1006/geno.1996.0547 }}</ref><ref name="pmid18417578">{{cite journal | author = Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L | title = Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes | journal = J Virol | volume = 82 | issue = 13 | pages = 6251–8 | year = 2008 | month = Jun | pmid = 18417578 | pmc = 2447047 | doi = 10.1128/JVI.00163-08 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IRF4 interferon regulatory factor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3662| accessdate = }}</ref> also known as ''MUM1''. In melanocytic cells the IRF4 gene may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | author = Hoek KS, Schlegel NC, Eichhoff OM, ''et al.'' | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref> IRF4 is a transcription factor that has been implicated in acute leukemia.<ref>Implication of IRF4 aberrant gene expression in the acute leukemias of childhood. PLoS One. 2013 Aug 15;8(8):e72326. doi: 10.1371/journal.pone.0072326.</ref> This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color (PMID: 24267888). |
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==Interactions== |
==Interactions== |
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Revision as of 13:37, 26 November 2013
Template:PBB Interferon regulatory factor 4 is a protein that in humans is encoded by the IRF4 gene,[1][2][3] also known as MUM1. In melanocytic cells the IRF4 gene may be regulated by MITF.[4] IRF4 is a transcription factor that has been implicated in acute leukemia.[5] This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color (PMID: 24267888).
Interactions
IRF4 has been shown to interact with STAT6,[6] NFATC2,[7] BCL6[6] and SPI1.[8][9]
See also
References
- ^ Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (1997). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics. 37 (2): 229–33. doi:10.1006/geno.1996.0547. PMID 8921401.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Xu D, Zhao L, Del Valle L, Miklossy J, Zhang L (2008). "Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes". J Virol. 82 (13): 6251–8. doi:10.1128/JVI.00163-08. PMC 2447047. PMID 18417578.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: IRF4 interferon regulatory factor 4".
- ^ Hoek KS, Schlegel NC, Eichhoff OM; et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ Implication of IRF4 aberrant gene expression in the acute leukemias of childhood. PLoS One. 2013 Aug 15;8(8):e72326. doi: 10.1371/journal.pone.0072326.
- ^ a b Gupta, S (1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. 190 (12). UNITED STATES: 1837–48. doi:10.1084/jem.190.12.1837. ISSN 0022-1007. PMC 2195723. PMID 10601358.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Rengarajan, Jyothi (2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". J. Exp. Med. 195 (8). United States: 1003–12. doi:10.1084/jem.20011128. ISSN 0022-1007. PMC 2193700. PMID 11956291.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Brass, A L (1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. 18 (4). ENGLAND: 977–91. doi:10.1093/emboj/18.4.977. ISSN 0261-4189. PMC 1171190. PMID 10022840.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ Escalante, Carlos R (2002). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. 139 (1). United States: 55–9. doi:10.1016/S1047-8477(02)00514-2. ISSN 1047-8477. PMID 12372320.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)
Further reading
- Mamane Y, Sharma S, Grandvaux N; et al. (2002). "IRF-4 activities in HTLV-I-induced T cell leukemogenesis". J. Interferon Cytokine Res. 22 (1): 135–43. doi:10.1089/107999002753452746. PMID 11846984.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Yamagata T, Nishida J, Tanaka S; et al. (1996). "A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes". Mol. Cell. Biol. 16 (4): 1283–94. PMC 231112. PMID 8657101.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Iida S, Rao PH, Butler M; et al. (1997). "Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma". Nat. Genet. 17 (2): 226–30. doi:10.1038/ng1097-226. PMID 9326949.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Brass AL, Zhu AQ, Singh H (1999). "Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers". EMBO J. 18 (4): 977–91. doi:10.1093/emboj/18.4.977. PMC 1171190. PMID 10022840.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1". J. Biol. Chem. 274 (16): 11115–24. doi:10.1074/jbc.274.16.11115. PMID 10196196.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Marecki S, Atchison ML, Fenton MJ (1999). "Differential expression and distinct functions of IFN regulatory factor 4 and IFN consensus sequence binding protein in macrophages". J. Immunol. 163 (5): 2713–22. PMID 10453013.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Gupta S, Jiang M, Anthony A, Pernis AB (2000). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. PMC 2195723. PMID 10601358.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Mamane Y, Sharma S, Petropoulos L; et al. (2000). "Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52". Immunity. 12 (2): 129–40. doi:10.1016/S1074-7613(00)80166-1. PMID 10714679.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Gupta S, Anthony A, Pernis AB (2001). "Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins". J. Immunol. 166 (10): 6104–11. PMID 11342629.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Imaizumi Y, Kohno T, Yamada Y; et al. (2002). "Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia". Jpn. J. Cancer Res. 92 (12): 1284–92. PMID 11749693.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Rengarajan J, Mowen KA, McBride KD; et al. (2002). "Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression". J. Exp. Med. 195 (8): 1003–12. doi:10.1084/jem.20011128. PMC 2193700. PMID 11956291.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Sharma S, Grandvaux N, Mamane Y; et al. (2002). "Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells". J. Immunol. 169 (6): 3120–30. PMID 12218129.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Escalante CR, Shen L, Escalante MC; et al. (2003). "Crystallization and characterization of PU.1/IRF-4/DNA ternary complex". J. Struct. Biol. 139 (1): 55–9. doi:10.1016/S1047-8477(02)00514-2. PMID 12372320.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Hu CM, Jang SY, Fanzo JC, Pernis AB (2003). "Modulation of T cell cytokine production by interferon regulatory factor-4". J. Biol. Chem. 277 (51): 49238–46. doi:10.1074/jbc.M205895200. PMID 12374808.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Fanzo JC, Hu CM, Jang SY, Pernis AB (2003). "Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4)". J. Exp. Med. 197 (3): 303–14. doi:10.1084/jem.20020717. PMC 2193834. PMID 12566414.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - O'Reilly D, Quinn CM, El-Shanawany T; et al. (2003). "Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner". J. Biol. Chem. 278 (24): 21909–19. doi:10.1074/jbc.M212150200. PMID 12676954.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Sundram U, Harvell JD, Rouse RV, Natkunam Y (2004). "Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA". Mod. Pathol. 16 (8): 802–10. doi:10.1097/01.MP.0000081726.49886.CF. PMID 12920225.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- FactorBook IRF4
- IRF4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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