CXCR5
Appearance
C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. In humans, the CXC-R5 protein is encoded by the CXCR5 gene.[1]
Tissue distribution and function
The BLR1 / CXCR5 gene is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes as well as in spleen. The gene plays an essential role in B cell migration.[2]
References
- ^ Dobner T, Wolf I, Emrich T, Lipp M (November 1992). "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma". Eur. J. Immunol. 22 (11): 2795–9. doi:10.1002/eji.1830221107. PMID 1425907.
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: CS1 maint: multiple names: authors list (link) - ^ Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (1996). "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen". Cell. 87 (6): 1037–47. doi:10.1016/S0092-8674(00)81798-5. PMID 8978608.
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Further reading
- Lipp M, Müller G (2006). "Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking". Verhandlungen der Deutschen Gesellschaft für Pathologie. 87: 90–101. PMID 16888899.
- Barella L, Loetscher M, Tobler A; et al. (1995). "Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation". Biochem. J. 309 (3): 773–9. PMC 1135699. PMID 7639692.
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: CS1 maint: multiple names: authors list (link) - Legler DF, Loetscher M, Roos RS; et al. (1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.
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: CS1 maint: multiple names: authors list (link) - Gunn MD, Ngo VN, Ansel KM; et al. (1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. doi:10.1038/35876. PMID 9486651.
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: CS1 maint: multiple names: authors list (link) - Müller G, Lipp M (2002). "Signal transduction by the chemokine receptor CXCR5: structural requirements for G protein activation analyzed by chimeric CXCR1/CXCR5 molecules". Biol. Chem. 382 (9): 1387–97. doi:10.1515/BC.2001.171. PMID 11688722.
- Schaerli P, Loetscher P, Moser B (2002). "Cutting edge: induction of follicular homing precedes effector Th cell development". J. Immunol. 167 (11): 6082–6. doi:10.4049/jimmunol.167.11.6082. PMID 11714765.
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: CS1 maint: multiple names: authors list (link) - Kim CH, Johnston B, Butcher EC (2002). "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity". Blood. 100 (1): 11–6. doi:10.1182/blood-2001-12-0196. PMID 12070001.
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: CS1 maint: multiple names: authors list (link) - Carlsen HS, Baekkevold ES, Johansen FE; et al. (2002). "B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue". Gut. 51 (3): 364–71. doi:10.1136/gut.51.3.364. PMC 1773345. PMID 12171958.
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: CS1 maint: multiple names: authors list (link) - Battle TE, Yen A (2002). "Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells". Exp. Biol. Med. (Maywood). 227 (9): 753–62. PMID 12324654.
- Lisignoli G, Toneguzzi S, Piacentini A; et al. (2003). "Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release". J. Cell. Physiol. 194 (1): 71–9. doi:10.1002/jcp.10188. PMID 12447991.
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: CS1 maint: multiple names: authors list (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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: CS1 maint: multiple names: authors list (link) - Chan CC, Shen D, Hackett JJ; et al. (2003). "Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma". Ophthalmology. 110 (2): 421–6. doi:10.1016/S0161-6420(02)01737-2. PMID 12578791.
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: CS1 maint: multiple names: authors list (link) - Flynn G, Maru S, Loughlin J; et al. (2003). "Regulation of chemokine receptor expression in human microglia and astrocytes". J. Neuroimmunol. 136 (1–2): 84–93. doi:10.1016/S0165-5728(03)00009-2. PMID 12620646.
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: CS1 maint: multiple names: authors list (link) - Lisignoli G, Piacentini A, Toneguzzi S; et al. (2004). "Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts". Biogerontology. 4 (5): 309–17. doi:10.1023/A:1026203502385. PMID 14618028.
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: CS1 maint: multiple names: authors list (link) - Aust G, Sittig D, Becherer L; et al. (2004). "The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases". Eur. J. Endocrinol. 150 (2): 225–34. doi:10.1530/eje.0.1500225. PMID 14763921.
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: CS1 maint: multiple names: authors list (link) - Howard OM, Dong HF, Su SB; et al. (2005). "Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate". Blood. 105 (11): 4207–14. doi:10.1182/blood-2004-07-2697. PMC 1895027. PMID 15713799.
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: CS1 maint: multiple names: authors list (link) - Steinmetz OM, Panzer U, Kneissler U; et al. (2005). "BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection". Kidney Int. 67 (4): 1616–21. doi:10.1111/j.1523-1755.2005.00244.x. PMID 15780119.
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: CS1 maint: multiple names: authors list (link) - Hu C, Xiong J, Zhang L; et al. (2006). "PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia". Cell. Mol. Immunol. 1 (4): 280–94. PMID 16225771.
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