CXCR5

Template:PBB

C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. In humans, the CXC-R5 protein is encoded by the CXCR5 gene.^[1]

Tissue distribution and function

The BLR1 / CXCR5 gene is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes as well as in spleen. The gene plays an essential role in B cell migration.^[2]

References

^ Dobner T, Wolf I, Emrich T, Lipp M (November 1992). "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma". Eur. J. Immunol. 22 (11): 2795–9. doi:10.1002/eji.1830221107. PMID 1425907.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (1996). "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen". Cell. 87 (6): 1037–47. doi:10.1016/S0092-8674(00)81798-5. PMID 8978608.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Lipp M, Müller G (2006). "Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking". Verhandlungen der Deutschen Gesellschaft für Pathologie. 87: 90–101. PMID 16888899.
Barella L, Loetscher M, Tobler A; et al. (1995). "Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation". Biochem. J. 309 (3): 773–9. PMC 1135699. PMID 7639692.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Legler DF, Loetscher M, Roos RS; et al. (1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Gunn MD, Ngo VN, Ansel KM; et al. (1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. doi:10.1038/35876. PMID 9486651.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Müller G, Lipp M (2002). "Signal transduction by the chemokine receptor CXCR5: structural requirements for G protein activation analyzed by chimeric CXCR1/CXCR5 molecules". Biol. Chem. 382 (9): 1387–97. doi:10.1515/BC.2001.171. PMID 11688722.
Schaerli P, Loetscher P, Moser B (2002). "Cutting edge: induction of follicular homing precedes effector Th cell development". J. Immunol. 167 (11): 6082–6. doi:10.4049/jimmunol.167.11.6082. PMID 11714765.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Kim CH, Johnston B, Butcher EC (2002). "Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity". Blood. 100 (1): 11–6. doi:10.1182/blood-2001-12-0196. PMID 12070001.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Carlsen HS, Baekkevold ES, Johansen FE; et al. (2002). "B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue". Gut. 51 (3): 364–71. doi:10.1136/gut.51.3.364. PMC 1773345. PMID 12171958.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Battle TE, Yen A (2002). "Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells". Exp. Biol. Med. (Maywood). 227 (9): 753–62. PMID 12324654.
Lisignoli G, Toneguzzi S, Piacentini A; et al. (2003). "Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release". J. Cell. Physiol. 194 (1): 71–9. doi:10.1002/jcp.10188. PMID 12447991.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Chan CC, Shen D, Hackett JJ; et al. (2003). "Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma". Ophthalmology. 110 (2): 421–6. doi:10.1016/S0161-6420(02)01737-2. PMID 12578791.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Flynn G, Maru S, Loughlin J; et al. (2003). "Regulation of chemokine receptor expression in human microglia and astrocytes". J. Neuroimmunol. 136 (1–2): 84–93. doi:10.1016/S0165-5728(03)00009-2. PMID 12620646.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Lisignoli G, Piacentini A, Toneguzzi S; et al. (2004). "Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts". Biogerontology. 4 (5): 309–17. doi:10.1023/A:1026203502385. PMID 14618028.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Aust G, Sittig D, Becherer L; et al. (2004). "The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases". Eur. J. Endocrinol. 150 (2): 225–34. doi:10.1530/eje.0.1500225. PMID 14763921.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Howard OM, Dong HF, Su SB; et al. (2005). "Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate". Blood. 105 (11): 4207–14. doi:10.1182/blood-2004-07-2697. PMC 1895027. PMID 15713799.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Steinmetz OM, Panzer U, Kneissler U; et al. (2005). "BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection". Kidney Int. 67 (4): 1616–21. doi:10.1111/j.1523-1755.2005.00244.x. PMID 15780119.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Hu C, Xiong J, Zhang L; et al. (2006). "PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia". Cell. Mol. Immunol. 1 (4): 280–94. PMID 16225771.{{cite journal}}: CS1 maint: multiple names: authors list (link)

This cell biology article is a stub. You can help Wikipedia by expanding it.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[pmid1425907-1] Dobner T, Wolf I, Emrich T, Lipp M (November 1992). "Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma". Eur. J. Immunol. 22 (11): 2795–9. doi:10.1002/eji.1830221107. PMID 1425907.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid8978608-2] Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (1996). "A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen". Cell. 87 (6): 1037–47. doi:10.1016/S0092-8674(00)81798-5. PMID 8978608.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[1]

[2]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Tissue distribution and function

References

Further reading