IRF3
Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.[1]
Function
IRF3 is a member of the interferon regulatory transcription factor (IRF) family.[1] IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. [2] IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP.[3] This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.[4]
IRF3 plays an important role in the innate immune system's response to viral infection. [5] Aggregated MAVS have been found to activate IRF3 dimerization. [6]
Interactions
IRF3 has been shown to interact with IRF7.[7]
References
- ^ a b Hiscott J, Pitha P, Genin P, Nguyen H, Heylbroeck C, Mamane Y, Algarte M, Lin R (1999). "Triggering the interferon response: the role of IRF-3 transcription factor". J. Interferon Cytokine Res. 19 (1): 1–13. doi:10.1089/107999099314360. PMID 10048763.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Lin, R.; Heylbroeck, C.; Genin, P.; Pitha, PM.; Hiscott, J. (1999). "Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription". Mol Cell Biol. 19 (2): 959–66. PMC 116027. PMID 9891032.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Yoneyama M, Suhara W, Fujita T (2002). "Control of IRF-3 activation by phosphorylation". J. Interferon Cytokine Res. 22 (1): 73–6. doi:10.1089/107999002753452674. PMID 11846977.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: IRF3 interferon regulatory factor 3".
- ^ Collins, SE.; Noyce, RS.; Mossman, KL. (2004). "Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication". J Virol. 78 (4): 1706–17. doi:10.1128/JVI.78.4.1706-1717.2004. PMC 369475. PMID 14747536.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Hou, F (2011 Aug 5). "MAVS Forms Functional Prion-Like Aggregates To Activate and Propagate Antiviral Innate Immune Response". Cell. 146 (3): 448–61. doi:10.1016/j.cell.2011.06.041. PMC 3179916. PMID 21782231.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)CS1 maint: date and year (link) - ^ Au, W C (2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology. 280 (2). United States: 273–82. doi:10.1006/viro.2000.0782. ISSN 0042-6822. PMID 11162841.
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Further reading
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External links
- Interferon+Regulatory+Factor-3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook IRF3
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