From Wikipedia, the free encyclopedia
The glucocorticoid receptor .
The corticosteroid receptors are receptors for corticosteroids .[ 1] They include the following two nuclear receptors :[ 1] [ 2] [ 3]
There are also membrane corticosteroid receptors , including the membrane glucocorticoid receptors and the membrane mineralocorticoid receptors , which are not well-characterized at present.[ 4] [ 5] [ 6]
References
^ a b Scott T. Brady; George J. Siegel; Robert Wayne Albers; Donald Lowell Price (2012). Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology . Academic Press. pp. 522–. ISBN 978-0-12-374947-5 .
^ Eugenia Wang; D. Stephen Snyder (13 August 1998). Handbook of the Aging Brain . Academic Press. pp. 22–. ISBN 978-0-08-053322-3 .
^ Hormones, Brain and Behavior, Five-Volume Set . Academic Press. 18 June 2002. pp. 267–. ISBN 978-0-08-053415-2 .
^ Groeneweg FL, Karst H, de Kloet ER, Joëls M (2012). "Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling". Mol. Cell. Endocrinol . 350 (2): 299–309. doi :10.1016/j.mce.2011.06.020 . PMID 21736918 .
^ Tasker JG, Di S, Malcher-Lopes R (2006). "Minireview: rapid glucocorticoid signaling via membrane-associated receptors" . Endocrinology . 147 (12): 5549–56. doi :10.1210/en.2006-0981 . PMC 3280589 . PMID 16946006 .
^ Dooley R, Harvey BJ, Thomas W (2012). "Non-genomic actions of aldosterone: from receptors and signals to membrane targets". Mol. Cell. Endocrinol . 350 (2): 223–34. doi :10.1016/j.mce.2011.07.019 . PMID 21801805 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group C bHLH-PAS Group D Group E Group F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
GR Tooltip Glucocorticoid receptor
MR Tooltip Mineralocorticoid receptor